The discussion is organized by types of mechanisms and the conditions under which the reaction is executed, rather than by the overall reaction as is the case in most textbooks. Each chapter discusses common mechanistic pathways and suggests practical tips for drawing them.
Worked problems are included in the discussion of each mechanism, and "common error alerts" are scattered throughout the text to warn readers about pitfalls and misconceptions that bedevil students. Each chapter is capped by a large problem set. The material in this book iscondensed into a manageable text of pages and presented in aclear and logical fashion, focusing purely on the basics of thesubject without going through exhaustive detail or repetitiveexamples.
The book aims to bridge the gap between undergraduateorganic chemistry textbooks and advanced level textbooks, beginningwith a basic introductory course and arranging the reactionmechanisms according to an ascending order of difficulty. As such,the author believes the book will be excellent primer for advancedpostgraduates Reaction Mechanisms in Organic Synthesis is written fromthe point of view of the synthetic organic chemist, enablingstudents and researchers to understand and expand on reactionscovered in foundation courses, and to apply them in a practicalcontext by designing syntheses.
As a further aid to the practicalresearch student, the content is organized according to theconditions under which a reaction is executed rather than by thetypes of mechanisms. Particular emphasis is placed on controllingstereospecificity and regiospecificity. Topics covered include: Transition metal mediated carbon-carbon bond formationreactions Use of stabilized carbanions, ylides and enamines forcarbon-carbon bond formation reactions, Advanced level use of oxidation and reduction reagents insynthesis.
As a modern text, this book stands out from its competitors dueto its comprehensive coverage of recently published research. Thebook contains specific examples from the latest literature,covering modern reactions and the latest procedural modifications. The focus on contemporary and synthetically useful reactionsensures that the contents are specifically relevant and attractiveto postgraduate students and industrial organic chemists.
This book takes a unique approach to show that a general problem-solving strategy is applicable to many of the common reactions of organic chemistry, demonstrating that logical and stepwise reasoning, in combination with a good understanding of the fundamentals, is a powerful tool to apply to the solution of problems. Sub-divided by functional group, the book uses a check-list approach to problem-solving using mechanistic organic chemistry as its basis.
Each mechanistic problem is presented as a two-page spread; the left-hand page introduces the problem and provides a stepwise procedure for working through the reaction mechanisms, with helpful hints about the underlying chemistry.
The right-hand page contains the full worked solution and summary. This revised edition includes the following updates: A new chapter which applies the problem solving strategy to ligand coupling reactions using transition metals Much-expanded set of fully worked problems Over 40 further problems with answers for tutors for use in tutorials How To Solve Organic Reaction Mechanisms: A Stepwise Approach is an essential workbook for all students studying organic chemistry, and a useful aide for teachers of undergraduate organic chemistry to use in their tutorials.
Miller and Solomon illustrate that understanding organic reactions is based on applying general principles rather than the rote memorization of unrelated processes, and, in turn, emphasize that writing mechanisms is a practical method of applying knowledge of previously encountered reactions and reaction conditions to new reactions.
Students and research chemists alike will find this book useful in providing a method of organizing and synthesizing an oftentimes overwhelming quantity of information into a set of general principles and guidelines for determining and describing organic reaction mechanisms. NEW TO THIS EDITION Illustrated with hundreds of chemical structures, all redrawn from the first edition, with added emphasis on three-dimensional structures and stereochemical aspects of reaction mechanisms Extensively rewritten and reorganized to make the presentation and format more accessible to first-year organic chemistry students, as well as advanced undergraduate and graduate students Chapter 6 is completely revised to streamline the treatment of pericyclic reactions, while introducing the principles underlying the symmetry operations and orbital correlation diagrams New appendixes in this edition contain easily referenced information on Lewis structures, chemical symbols and notation, and relative acidities of common functional groups.
These methods have the potential for developing more "green" chemical synthesis. Over recent years, modern investigations have clarified the mechanisms of important organic electrochemical reactions. Progress has also been made in controlling the reactivity of intermediates through either radical or ionic pathways.
Now is the time to gather all the electrochemical work into a textbook. As an essential addition to the armory of synthetic organic chemists, electrochemical reactions give results not easily achieved by many other chemical routes. This book presents a logical development of reactions and mechanisms in organic electrochemistry at a level suited to research scientists and final year graduate students.
It forms an excellent starting point from which synthetic organic chemists, in both academia and industry, can appreciate uses for electrochemical methods in their own work. The book is also a reference guide to the literature. It starts from the absolute basics - counting the numbers of electrons around a simple atom. Then, in small steps, the text progresses to advanced mechanisms.
The text is in the form of interactive sections, which are designed to facilitate the assimilation of the information conveyed, so that by the end the student should already know the contents without the need for extensive revision.
Then, in small steps, the text progresses to advanced mechanisms. The text is in the form of interactive sections, which are designed to facilitate the assimilation of the information conveyed, so that by the end the student should already know the contents without the need for extensive revision. The material in this book iscondensed into a manageable text of pages and presented in aclear and logical fashion, focusing purely on the basics of thesubject without going through exhaustive detail or repetitiveexamples.
The book aims to bridge the gap between undergraduateorganic chemistry textbooks and advanced level textbooks, beginningwith a basic introductory course and arranging the reactionmechanisms according to an ascending order of difficulty.
As such,the author believes the book will be excellent primer for advancedpostgraduates Reaction Mechanisms in Organic Synthesis is written fromthe point of view of the synthetic organic chemist, enablingstudents and researchers to understand and expand on reactionscovered in foundation courses, and to apply them in a practicalcontext by designing syntheses.
As a further aid to the practicalresearch student, the content is organized according to theconditions under which a reaction is executed rather than by thetypes of mechanisms. Particular emphasis is placed on controllingstereospecificity and regiospecificity. Topics covered include: Transition metal mediated carbon-carbon bond formationreactions Use of stabilized carbanions, ylides and enamines forcarbon-carbon bond formation reactions, Advanced level use of oxidation and reduction reagents insynthesis.
As a modern text, this book stands out from its competitors dueto its comprehensive coverage of recently published research. Thebook contains specific examples from the latest literature,covering modern reactions and the latest procedural modifications.
The focus on contemporary and synthetically useful reactionsensures that the contents are specifically relevant and attractiveto postgraduate students and industrial organic chemists. A summary of oxidation and reduction of organic compounds is given in tabular form correlation tables for the convenience of students. The most commonly encountered reaction intermediates are dealt with. Applications of organic reagents illustrated with examples and problems at the end of each chapter will enable students to evaluate their understanding of the topic.
The book emphasizes that derivation of a mechanism is not a theoretical procedure, but a means of applying knowledge of other similar reactions and reaction conditions to the new reaction. These methods have the potential for developing more "green" chemical synthesis.
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